The UnBox Entrepreneurship Center at Bar-Ilan University is a platform for founding research-based startups aiming for positive global impact, currently focused on the healthcare domain. The bi-annual program introduced startup success factors through an open-to-all theoretic semester of inspiration, and a semester of applied acceleration based on the Customer Development Methodology for select co-founder teams. UnBox invests in its startups personalized coaching, pre-seed investment and a broad intellectual property release – in exchange for a minority stake in the startup. In its first two cohorts UnBox offered inspiration to ~200 members of its research community who submitted ~50 applications from which sprouted eight startups. More than 750 attendees signed up for the third inspiration semester (Fall 2020).